Sleep Heart Health Study: Association of Sleep-Disordered Breathing with Cardiovascular Disease

The Sleep Heart Health Study (SHHS) was the first large community-based cohort study to examine the relationship between sleep-disordered breathing and cardiovascular disease.

Prospective cohort study (n=6,132) with overnight polysomnography and cardiovascular outcomes follow-up.

Sleep-disordered breathing (AHI ≥11) was independently associated with self-reported cardiovascular disease (OR 1.42). Strongest associations with heart failure and stroke. Dose-response relationship with AHI severity.

OSA is independently associated with cardiovascular disease, particularly heart failure and stroke. This epidemiological foundation supports treating OSA in patients with cardiovascular risk. Know the AHI thresholds: mild 5–14, moderate 15–29, severe ≥30.

Cross-sectional cardiovascular assessment at baseline. Self-reported cardiovascular disease. Causality not established.